Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

• Main Authors: Marc P Hübner (Author), Coralie Martin (Author), Sabine Specht (Author), Marianne Koschel (Author), Bettina Dubben (Author), Stefan J Frohberger (Author), Alexandra Ehrens (Author), Martina Fendler (Author), Dominique Struever (Author), Edward Mitre (Author), Nathaly Vallarino-Lhermitte (Author), Suzanne Gokool (Author), Sara Lustigman (Author), Manfred Schneider (Author), Simon Townson (Author), Achim Hoerauf (Author), Ivan Scandale (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic shown to be well tolerated in phase 1 clinical trials....