Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

• Main Authors: Celia Chao (Author), John R Zatarain (Author), Ye Ding (Author), Ciro Coletta (Author), Amy A Mrazek (Author), Nadiya Druzhyna (Author), Paul Johnson (Author), Haiying Chen (Author), Judy L Hellmich (Author), Antonia Asimakopoulou (Author), Kazunori Yanagi (Author), Gabor Olah (Author), Petra Szoleczky (Author), Gabor Törö (Author), Fredrick J Bohanon (Author), Minal Cheema (Author), Rachel Lewis (Author), David Eckelbarger (Author), Akbar Ahmad (Author), Katalin Módis (Author), Ashley Untereiner (Author), Bartosz Szczesny (Author), Andreas Papapetropoulos (Author), Jia Zhou (Author), Mark R Hellmich (Author), Csaba Szabo (Author)
• Format: Book
• Published: BMC, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Colon cancer cells contain high levels of cystathlonlne-β-synthase (CBS). Its product, hydrogen sulfide (H2S), promotes the growth and proliferation of colorectal tumor cells. To improve the antitumor efficacy of the prototypical CBS inhibitor aminooxyacetic acid (AOAA), we have designed an...