A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar.

• المؤلفون الرئيسيون: James A Watson (مؤلف), Thomas Lamb (مؤلف), Jane Holmes (مؤلف), David A Warrell (مؤلف), Khin Thida Thwin (مؤلف), Zaw Lynn Aung (مؤلف), Min Zaw Oo (مؤلف), Myat Thet Nwe (مؤلف), Frank Smithuis (مؤلف), Elizabeth A Ashley (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2020-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

For most antivenoms there is little information from clinical studies to infer the relationship between dose and efficacy or dose and toxicity. Antivenom dose-finding studies usually recruit too few patients (e.g. fewer than 20) relative to clinically significant event rates (e.g. 5%). Model based a...