Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [<sup>18</sup>F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors for cancer therapy. The aim of this work is the...

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Main Authors: Oliver Clauß (Author), Linda Schäker-Hübner (Author), Barbara Wenzel (Author), Magali Toussaint (Author), Winnie Deuther-Conrad (Author), Daniel Gündel (Author), Rodrigo Teodoro (Author), Sladjana Dukić-Stefanović (Author), Friedrich-Alexander Ludwig (Author), Klaus Kopka (Author), Peter Brust (Author), Finn K. Hansen (Author), Matthias Scheunemann (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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