Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

• Main Authors: Bart A.W. Jacobs (Author), Maarten J. Deenen (Author), Markus Joerger (Author), Hilde Rosing (Author), Niels deVries (Author), Didier Meulendijks (Author), Annemieke Cats (Author), Jos H. Beijnen (Author), Jan H.M. Schellens (Author), Alwin D.R. Huitema (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Capecitabine is an oral prodrug of the anticancer drug 5‐fluorouracil (5‐FU). The primary aim of this study was to develop a pharmacokinetic model for capecitabine and its metabolites, 5'‐deoxy‐5‐fluorocytidine (dFCR), 5'‐deoxy‐5‐fluorouridine (dFUR), 5‐FU, and fluoro‐β‐alanine (FBAL) usin...