Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-<i>a</i>]pyridine Antileishmanial Pharmacophore

• Main Authors: Romain Paoli-Lombardo (Author), Nicolas Primas (Author), Sandra Bourgeade-Delmas (Author), Sébastien Hutter (Author), Alix Sournia-Saquet (Author), Clotilde Boudot (Author), Emilie Brenot (Author), Caroline Castera-Ducros (Author), Sophie Corvaisier (Author), Marc Since (Author), Aurélie Malzert-Fréon (Author), Bertrand Courtioux (Author), Alexis Valentin (Author), Pierre Verhaeghe (Author), Nadine Azas (Author), Pascal Rathelot (Author), Patrice Vanelle (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An antileishmanial structure-activity relationship (SAR) study focused on positions 2 and 8 of the imidazo[1,2-<i>a</i>]pyridine ring was conducted through the synthesis of 22 new derivatives. After being screened on the promatigote and axenic amastigote stages of <i>Leishmania don...