Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart

• Main Authors: Javad Garousi (Author), Tianqi Xu (Author), Yongsheng Liu (Author), Olga Vorontsova (Author), Sophia Hober (Author), Anna Orlova (Author), Vladimir Tolmachev (Author), Torbjörn Gräslund (Author), Anzhelika Vorobyeva (Author)
• 格式: 图书
• 出版: MDPI AG, 2022-08-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Overexpression of the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancer is exploited for targeted therapy using monoclonal antibodies and antibody-drug conjugates. Small engineered scaffold proteins, such as the albumin binding domain (ABD) derived affinity proteins (ADAPT...