Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

• Main Authors: Sarah Römer (Author), Marleen J. Meyer (Author), Kathrin Klein (Author), Lennart V. Schneider (Author), Johannes Matthaei (Author), Ana Tzvetkova (Author), Joanna Łapczuk-Romańska (Author), Jochen Gaedcke (Author), Marek Droździk (Author), Jürgen Brockmöller (Author), Anne T. Nies (Author), Mladen V. Tzvetkov (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated with altered pharmacokinetics and efficacy of drug...