Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy

• Main Authors: Jiayi Ye (Author), Bo Hou (Author), Fangmin Chen (Author), Shunan Zhang (Author), Muya Xiong (Author), Tianliang Li (Author), Yechun Xu (Author), Zhiai Xu (Author), Haijun Yu (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer immunotherapy is impaired by the intrinsic and adaptive immune resistance. Herein, a bispecific prodrug nanoparticle was engineered for circumventing immune evasion of the tumor cells by targeting multiple immune resistance mechanisms. A disulfide bond-linked bispecific prodrug of NLG919 and...