Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature.

• Main Authors: Camila Farias Amorim (Author), Fernanda O Novais (Author), Ba T Nguyen (Author), Mauricio T Nascimento (Author), Jamile Lago (Author), Alexsandro S Lago (Author), Lucas P Carvalho (Author), Daniel P Beiting (Author), Phillip Scott (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, transcriptional a...