Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature.

• Hlavní autoři: Camila Farias Amorim (Autor), Fernanda O Novais (Autor), Ba T Nguyen (Autor), Mauricio T Nascimento (Autor), Jamile Lago (Autor), Alexsandro S Lago (Autor), Lucas P Carvalho (Autor), Daniel P Beiting (Autor), Phillip Scott (Autor)
• Médium: Kniha
• Vydáno: Public Library of Science (PLoS), 2021-04-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, transcriptional a...