Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer

• Main Authors: Xiaohu Zeng (Author), Xin Zhu (Author), Qikang Tian (Author), Xiaoke Tan (Author), Ning Sun (Author), Min Yan (Author), Junwei Zhao (Author), Xiangxiang Wu (Author), Ruiqin Li (Author), Zhenqiang Zhang (Author), Huahui Zeng (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Celastrol is a promising antitumor drug candidate, but the poor water solubility and cytotoxicity limit its clinical application. Herein, we synthesized a Celastrol (Cel)-chitosan oligosaccharide (CSO) conjugate (Cel-CSO) for drug delivery. Celastrol was conjugated to a CSO backbone via amide bond f...