Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies

• Main Authors: Boris Grinshpun (Author), Nels Thorsteinson (Author), Joao NS Pereira (Author), Friedrich Rippmann (Author), David Nannemann (Author), Vanita D. Sood (Author), Yves Fomekong Nanfack (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding the pharmacokinetic (PK) properties of a drug, such as clearance, is a crucial step for evaluating efficacy. The PK of therapeutic antibodies can be complex and is influenced by interactions with the target, Fc-receptors, anti-drug antibodies, and antibody intrinsic factors. A growing...