A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA

• Main Authors: Zhengyang Zeng (Author), Shisong Han (Author), Wei Hong (Author), Yange Lang (Author), Fangfang Li (Author), Yongxiang Liu (Author), Zeyong Li (Author), Yingliang Wu (Author), Wenxin Li (Author), Xianzheng Zhang (Author), Zhijian Cao (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all of which are severe threats to human health. However, current clinical therapies for HBV are limited by potential side effects, toxicity, and drug-resistance. In this...