P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

• Main Authors: Romain Lara (Author), Elena Adinolfi (Author), Catherine A. Harwood (Author), Mike Philpott (Author), Julian A. Barden (Author), Francesco Di Virgilio (Author), Shaun McNulty (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response. Upon activation by its main ligand, extracellular ATP, P2X...