Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

• Главные авторы: ZiSheng Chen (Автор), Dongbo Tian (Автор), Xiaowen Liao (Автор), Yifei Zhang (Автор), Jinghua Xiao (Автор), Weiping Chen (Автор), Qingxia Liu (Автор), Yun Chen (Автор), Dongmin Li (Автор), Lianyu Zhu (Автор), Shaoxi Cai (Автор)
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• Опубликовано: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Предметы: article
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Cancer cells are characterized by abnormally increased glucose uptake and active bio-energy and biosynthesis to support the proliferation, metastasis, and drug resistant survival. We examined the therapeutic value of the combination of apigenin (a natural small-molecule inhibitor of Glut1 belonging...