Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

• Main Authors: ZiSheng Chen (Author), Dongbo Tian (Author), Xiaowen Liao (Author), Yifei Zhang (Author), Jinghua Xiao (Author), Weiping Chen (Author), Qingxia Liu (Author), Yun Chen (Author), Dongmin Li (Author), Lianyu Zhu (Author), Shaoxi Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells are characterized by abnormally increased glucose uptake and active bio-energy and biosynthesis to support the proliferation, metastasis, and drug resistant survival. We examined the therapeutic value of the combination of apigenin (a natural small-molecule inhibitor of Glut1 belonging...