Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response

• Main Authors: Rukmini Kumar (Author), Kannan Thiagarajan (Author), Lakshmanan Jagannathan (Author), Liming Liu (Author), Kapil Mayawala (Author), Dinesh deAlwis (Author), Brian Topp (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A quantitative systems pharmacology model for metastatic melanoma was developed for immuno‐oncology with the goal of predicting efficacy of combination checkpoint therapy with pembrolizumab and ipilimumab. This literature‐based model is developed at multiple scales: (i) tumor and immune cel...