Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

• Main Authors: Teodor-D. Brumeanu (Author), Pooja Vir (Author), Ahmad Faisal Karim (Author), Swagata Kar (Author), Dalia Benetiene (Author), Megan Lok (Author), Jack Greenhouse (Author), Tammy Putmon-Taylor (Author), Christopher Kitajewski (Author), Kevin K. Chung (Author), Kathleen P. Pratt (Author), Sofia A. Casares (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report a Human Immune System (HIS)-humanized mouse model ("DRAGA": HLA-A2.HLA-DR4.Rag1KO.IL-2 RγcKO.NOD) for COVID-19 research. DRAGA mice express transgenically HLA-class I and class-II molecules in the mouse thymus to promote human T cell development and human B cell Ig-class switchin...