Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

• Main Authors: Yifan Chen (Author), Xuejing Shao (Author), Ji Cao (Author), Hong Zhu (Author), Bo Yang (Author), Qiaojun He (Author), Meidan Ying (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of substrates or receptors of CRLs, can alter their intera...