Development of Clarstatin, a Novel Drug Lead for the Therapy of Autoimmune Uveitis

• Main Authors: Shira Merzbach (Author), Amnon Hoffman (Author), Philip Lazarovici (Author), Chaim Gilon (Author), Radgonde Amer (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid sequence (Q/D)¹-(R/K)²-X³-X⁴-A⁵...