Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei

• Main Authors: Daniela Vullo (Author), Sonia Del Prete (Author), Sameh M. Osman (Author), Fatmah A. S. Alasmary (Author), Zeid AlOthman (Author), William A. Donald (Author), Clemente Capasso (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The β-class carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Burkholderia pseudomallei, BpsCAβ, that is responsible for the tropical disease melioidosis was investigated for its activation with natural and non-natural amino acids and amines. Previously, the γ-CA from this bacterium...