Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma

• Egile Nagusiak: Ying Shen (Egilea), Bin Zhang (Egilea), Yanwei Su (Egilea), Shaikh Atik Badshah (Egilea), Xiaofei Wang (Egilea), Xin Li (Egilea), Yanru Xue (Egilea), Li Xie (Egilea), Zhe Wang (Egilea), Zhouqi Yang (Egilea), Ge Zhang (Egilea), Peng Shang (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Osteosarcoma cellular iron concentration is higher than that in normal bone cells and other cell types. High levels of cellular iron help catalyze the Fenton reaction to produce reactive oxygen species (ROS), which promotes cancer cell proliferation. Dihydroartemisinin (DHA), a classic anti-malarial...