mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models

• Päätekijät: Lanlan Tang (Tekijä), Yu Fu (Tekijä), Jiarun Song (Tekijä), Taibing Hu (Tekijä), Kun Li (Tekijä), Zhi Li (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2022-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value. TAK‐228 is a potent inhibitor of mTOR1 and 2 with preclinical activity in a variety of cancers. In this s...