Beyond <em>LKB1</em> Mutations in Non-Small Cell Lung Cancer: Defining LKB1less Phenotype to Optimize Patient Selection and Treatment

• Main Authors: Cristina Borzi (Author), Giulia Galli (Author), Monica Ganzinelli (Author), Diego Signorelli (Author), Claudio Vernieri (Author), Marina Chiara Garassino (Author), Gabriella Sozzi (Author), Massimo Moro (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LKB1 is frequently mutated in non-small cell lung cancer (NSCLC). LKB1-mutated NSCLCs often have a dismal prognosis and receive lower benefit from the currently available therapies. LKB1 acts as a cell emergency brake in low-energy conditions, by modulating the activity of crucial anabolic enzymes....