Optimization and evaluation of Lisinopril mucoadhesive sustained release matrix pellets: In-vitro and ex-vivo studies

• Главные авторы: Modhi F. Alagili (Автор), Bushra T. AlQuadeib (Автор), Lubna Y. Ashri (Автор), Mohamed Abbas Ibrahim (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-08-01T00:00:00Z.
• Предметы: article
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Lisinopril (LIS) is antihypertensive drug, classified as a class III drug with high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR) matrix pellet by extrusion/spheronization. Matrix pellets were comp...