Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii Hook F, has an excellent pharmacological profile of immunosuppression and anti-tumor activities, but its clinical applications are severely restricted due to its severe and cumulative toxicities. The farnesoid X receptor (FXR) is th...

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Main Authors: Jing Yang (Author), Lixin Sun (Author), Lu Wang (Author), Hozeifa M. Hassan (Author), Xuan Wang (Author), Phillip B. Hylemon (Author), Tao Wang (Author), Huiping Zhou (Author), Luyong Zhang (Author), Zhenzhou Jiang (Author)
Format: Book
Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
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