Cover Image

Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii Hook F, has an excellent pharmacological profile of immunosuppression and anti-tumor activities, but its clinical applications are severely restricted due to its severe and cumulative toxicities. The farnesoid X receptor (FXR) is th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jing Yang (Author), Lixin Sun (Author), Lu Wang (Author), Hozeifa M. Hassan (Author), Xuan Wang (Author), Phillip B. Hylemon (Author), Tao Wang (Author), Huiping Zhou (Author), Luyong Zhang (Author), Zhenzhou Jiang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2017-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability
by: Wang Zhou, et al.
Published: (2018)

Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity
by: Hozeifa M. Hassan, et al.
Published: (2018)

Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury
by: Xinzhi eWang, et al.
Published: (2016)

A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein
by: Ziqiao Yuan, et al.
Published: (2020)

Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice
by: Yingying Miao, et al.
Published: (2022)

Sex-related differences of lipid metabolism induced by triptolide: The possible role of the LXRα/SREBP-1 signaling pathway
by: Zhenzhou eJiang, et al.
Published: (2016)

Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism
by: Eric Kwong, et al.
Published: (2015)

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model
by: Linxi Yu, et al.
Published: (2017)

The molecular pathogenesis of triptolide-induced hepatotoxicity
by: Yeqing Hu, et al.
Published: (2022)

TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy
by: Dengqiu Xu, et al.
Published: (2021)

A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1
by: Dengqiu Xu, et al.
Published: (2020)

Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A
by: Haowei Tong, et al.
Published: (2024)

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
by: Tingting Qin, et al.
Published: (2022)

SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
by: Shuang Cui, et al.
Published: (2023)

Lactobacillus rhamnosus GG ameliorates triptolide-induced liver injury through modulation of the bile acid-FXR axis
by: Shiping Hu, et al.
Published: (2024)

Extracellular Vesicles Derived from Lung Cancer Cells Induce Transformation of Normal Fibroblasts into Lung Cancer-Associated Fibroblasts and Promote Metastasis of Lung Cancer by Delivering lncRNA HOTAIR
by: Xiaoxuan Zhang, et al.
Published: (2022)

A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
by: Tailin He, et al.
Published: (2021)

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress
by: Yadi Zhong, et al.
Published: (2022)

Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation
by: Man Li, et al.
Published: (2022)

In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism
by: Jun-Ming Wang, et al.
Published: (2018)

Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles
by: Duanping Sun, et al.
Published: (2023)

Inflammation aggravated the hepatotoxicity of triptolide by oxidative stress, lipid metabolism disorder, autophagy, and apoptosis in zebrafish
by: Chenqinyao Li, et al.
Published: (2022)

Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide
by: Qian-Qian Shan, et al.
Published: (2019)

The Effect of Triptolide Combined With Crocin on Arthritis in Mice: From Side Effect Attenuation to Therapy
by: Min Yan, et al.
Published: (2022)

Dynamic structures and emerging trends in the management of major trauma: A bibliometric analysis of publications between 2012 and 2021
by: Zhe Du, et al.
Published: (2022)

Triptolide Attenuates Vascular Calcification by Upregulating Expression of miRNA-204
by: Yu-qiang Pei, et al.
Published: (2021)

Research Progress of Triptolide Against Fibrosis
by: Jiang M, et al.
Published: (2024)

Metal-organic framework-based electrochemical aptasensors for detecting cancer biomarkers
by: Maoqiang WU, et al.
Published: (2022)

Correction: Zhang et al. Bimodal Imaging of Tumors via Genetically Engineered <i>Escherichia coli</i>. <i>Pharmaceutics</i> 2022, <i>14</i>, 1804
by: Linlin Zhang, et al.
Published: (2023)

Bimodal Imaging of Tumors via Genetically Engineered <i>Escherichia coli</i>
by: Linlin Zhang, et al.
Published: (2022)

Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice
by: Chuangzhen Lin, et al.
Published: (2022)

Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway
by: Qin-You Tan, et al.
Published: (2018)

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters
by: Zhenyan Hou, et al.
Published: (2018)

Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy
by: Yuan-Yuan Ding, et al.
Published: (2016)

Quercetin Attenuates Cardiac Hypertrophy by Inhibiting Mitochondrial Dysfunction Through SIRT3/PARP-1 Pathway
by: Wen-Jing Chen, et al.
Published: (2021)

Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway
by: Meng Wang, et al.
Published: (2019)

USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis
by: Zhiwen Zhang, et al.
Published: (2024)

The therapeutic potential of triptolide and celastrol in neurological diseases
by: Yueran Cui, et al.
Published: (2022)

Effects Of Triptolide On Tooth Movement And Root Resorption In Rats
by: Yang F, et al.
Published: (2019)

Characterization and Comparison of Contrast Imaging Properties of Naturally Isolated and Heterologously Expressed Gas Vesicles
by: Tingting Liu, et al.
Published: (2024)