Application of a Physiologically Based Pharmacokinetic Model to Predict Cefazolin and Cefuroxime Disposition in Obese Pregnant Women Undergoing Caesarean Section

Application of a Physiologically Based Pharmacokinetic Model to Predict Cefazolin and Cefuroxime Disposition in Obese Pregnant Women Undergoing Caesarean Section

Intravenous (IV) cefuroxime and cefazolin are used prophylactically in caesarean sections (CS). Currently, there are concerns regarding sub-optimal dosing in obese pregnant women compared to lean pregnant women prior to CS. The current study used a physiologically based pharmacokinetic (PBPK) approa...

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Main Authors: Hanadi H. Alrammaal (Author), Khaled Abduljalil (Author), Victoria Hodgetts Morton (Author), R. Katie Morris (Author), John F. Marriott (Author), Hsu P. Chong (Author), Hannah K. Batchelor (Author)
Format: Book
Published: MDPI AG, 2022-05-01T00:00:00Z.
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