NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos

• Main Authors: Sandra Mercier (Author), Véronique David (Author), Leslie Ratié (Author), Isabelle Gicquel (Author), Sylvie Odent (Author), Valérie Dupé (Author)
• Formato: Libro
• Publicado: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

SUMMARY Holoprosencephaly (HPE) is a common congenital defect that results from failed or incomplete forebrain cleavage. HPE is characterized by a wide clinical spectrum, with inter- and intrafamilial variability. This heterogeneity is not well understood and it has been suggested that HPE involves...