Model-Informed Target Morning 17α-Hydroxyprogesterone Concentrations in Dried Blood Spots for Pediatric Congenital Adrenal Hyperplasia Patients

• Main Authors: Viktoria Stachanow (Author), Uta Neumann (Author), Oliver Blankenstein (Author), Nele Alder-Baerens (Author), Davide Bindellini (Author), Peter Hindmarsh (Author), Richard J. Ross (Author), Martin J. Whitaker (Author), Johanna Melin (Author), Wilhelm Huisinga (Author), Robin Michelet (Author), Charlotte Kloft (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monitoring cortisol replacement therapy in congenital adrenal hyperplasia (CAH) patients is vital to avoid serious adverse events such as adrenal crises due to cortisol underexposure or metabolic consequences due to cortisol overexposure. The less invasive dried blood spot (DBS) sampling is an advan...