Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1

• Main Authors: Xiao-hui Li (Author), Xia Gong (Author), Li Zhang (Author), Rong Jiang (Author), Hong-zhong Li (Author), Meng-jiao Wu (Author), Jing-yuan Wan (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung in...