Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays

• Main Authors: Elena Cichero (Author), Valeria Francesconi (Author), Beatrice Casini (Author), Monica Casale (Author), Evgeny Kanov (Author), Andrey S. Gerasimov (Author), Ilya Sukhanov (Author), Artem Savchenko (Author), Stefano Espinoza (Author), Raul R. Gainetdinov (Author), Michele Tonelli (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible structural similarity with endogenous ligands, most of the agonists developed so far resulted in being affected by a low sel...