Efficacy of vitamin E in oral submucous fibrosis: A clinical and histopathologic study
Introduction: Oral submucous fibrosis is a scarring progressive disease characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues, i.e., lamina propria and deeper connective tissues. An attempt was made in this study to evaluate the role of vitamin E...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2015-01-01T00:00:00Z.
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| Summary: | Introduction: Oral submucous fibrosis is a scarring progressive disease characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues, i.e., lamina propria and deeper connective tissues. An attempt was made in this study to evaluate the role of vitamin E in the treatment of oral submucous fibrosis by carrying out a comparative study between regular intralesional dexamethasone, hyaluronidase, and local anesthesia with and without oral vitamin E capsules. Materials and Methods: Twenty histopathologically confirmed oral submucous fibrosis cases were randomly selected and divided into two groups, with 10 cases in each group. Group A patients were given intralesional dexamethasone 2 ml (2 mg/ml), hyaluronidase (1500 IU), and 0.2 cc lignocaine (2%), every week. In addition, group B patients were given oral vit E capsules, 400 IU OD, for a period of 8 weeks. Weekly follow-ups were done. Results: Addition of vitamin E to the conventional treatment had synergistic effect with more improvement in the patient's condition in terms of burning sensation, vesiculation/ulceration, pigmentation, paleness of oral mucosa, tongue protrusion, and extent of mouth opening, which was confirmed histopathologically. Conclusion: Vitamin E has a significant role in the improvement of oral submucous fibrosis, which was proven in the present study. |
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| Item Description: | 0972-1363 0975-1572 10.4103/0972-1363.170467 |