A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies

• Main Authors: Alicia Arranz-Romera (Author), Maria Hernandez (Author), Patricia Checa-Casalengua (Author), Alfredo Garcia-Layana (Author), Irene T. Molina-Martinez (Author), Sergio Recalde (Author), Michael J. Young (Author), Budd A. Tucker (Author), Rocío Herrero-Vanrell (Author), Patricia Fernandez-Robredo (Author), Irene Bravo-Osuna (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We assessed the sustained delivery effect of poly (lactic-co-glycolic) acid (PLGA)/vitamin E (VitE) microspheres (MSs) loaded with glial cell-derived neurotrophic factor (GDNF) alone (GDNF-MSs) or combined with brain-derived neurotrophic factor (BDNF; GDNF/BDNF-MSs) on migration of the human adult r...