Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway

Abstract Background To explore whether nobiletin has a protective effect on high-fat diet (HFD)-induced enteric nerve injury and its underlying mechanism. Methods An obesity model was induced by a HFD. Nobiletin (100 mg/kg and 200 mg/kg) and vehicle were administered by gastric gavage for 4 weeks. L...

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Main Authors: Yueshan Pang (Author), Li Zhang (Author), Zhuoting Zhong (Author), Ni Yang (Author), Yali Zheng (Author), Weijun Ding (Author)
Format: Book
Published: BMC, 2024-08-01T00:00:00Z.
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