Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs) represent successful examples of targeted drug-delivery technologies for overcoming unwanted side effects of conventional chemotherapy in cancer treatment. In both strategies, a cytotoxic payload is connected to the tumor hom...

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Main Authors: Marco Zambra (Author), Ivan Ranđelović (Author), Francesco Talarico (Author), Adina Borbély (Author), Laura Svajda (Author), József Tóvári (Author), Gábor Mező (Author), Lizeth Bodero (Author), Sveva Colombo (Author), Federico Arrigoni (Author), Elettra Fasola (Author), Silvia Gazzola (Author), Umberto Piarulli (Author)
Format: Book
Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
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