Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization

• Main Authors: Jun Li (Author), Qiang Zhang (Author), Hao Yang (Author), Wenli Lu (Author), Yulong Fu (Author), Yingcai Xiong (Author), Xuan Wang (Author), Tianming Lu (Author), Yanlin Xin (Author), Zejuan Xie (Author), Weichao Chen (Author), Guoqiang Wang (Author), Yuanyuan Guo (Author), Ruogu Qi (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selective activation of Pt(IV) prodrugs within tumors has emerged as a promising strategy in tumor treatment. Although progress has been made with photo- and ultrasound-activated Pt(IV) prodrugs, concerns remain over the non-specific activation of photosensitizers (PS) and the potential for phototox...