Formulation, in vitro and in vivo evaluation of olanzapine nanoparticles dissolving microneedles for transdermal delivery

Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for the treatment of schizophrenia. Its oral bioavailability is 60% due to its low solubility and pre-systemic metabolism. Hence, the present work aims to formulate and evaluate OLZ nanoparticles dissolving microneedles (MNs) fo...

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Main Authors: Abulfadhel J. Neamah Al-Shaibani (Author), Mowafaq M. Ghareeb (Author)
Format: Book
Published: Pensoft Publishers, 2024-05-01T00:00:00Z.
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