Novel heterocyclic hybrid of 2-(aryl)-1H-indene-1,3(2H)-dione targeting tyrosinase: design, biological evaluation and in silico studies

• Main Authors: Aida Iraji (Author), Ali Nemati (Author), Hona Hosseinpoor (Author), Najmeh Edraki (Author), mahsima Khoshneviszadeh (Author), Mahshid Attarroshan (Author), Hossein Sadeghpour (Author), Mehdi Khoshneviszadeh (Author)
• Format: Book
• Published: Shiraz University of Medical Sciences, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melanogenesis is a process of melanin synthesize, which is a primary response for the pigmentation of human skin. Tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin formation, natural products have shown potent inhibitors, but some of these possess toxicity. Numerous syn...