Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages

• Main Authors: Jonathan R. Erlich (Author), Eunice E. To (Author), Raymond Luong (Author), Felicia Liong (Author), Stella Liong (Author), Osezua Oseghale (Author), Mark A. Miles (Author), Steven Bozinovski (Author), Robert D. Brooks (Author), Ross Vlahos (Author), Stanley Chan (Author), John J. O'Leary (Author), Doug A. Brooks (Author), Stavros Selemidis (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages undergo a metabolic switch from oxidative phosphorylation to glycolysis when exposed to gram-negative bacterial lipopolysaccharide (LPS), which modulates antibacterial host defence mechanisms. Here, we show that LPS treatment of macrophages increased the classical oxidative burst respons...