A drug‐disease model for predicting survival in an Ebola outbreak

• Main Authors: Masood Khaksar Toroghi (Author), Nidal Al‐Huniti (Author), John D. Davis (Author), A. Thomas DiCioccio (Author), Ronda Rippley (Author), Alina Baum (Author), Christos A. Kyratsous (Author), Sumathi Sivapalasingam (Author), Joel Kantrowitz (Author), Mohamed A. Kamal (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract REGN‐EB3 (Inmazeb) is a cocktail of three human monoclonal antibodies approved for treatment of Ebola infection. This paper describes development of a mathematical model linking REGN‐EB3's inhibition of Ebola virus to survival in a non‐human primate (NHP) model, and translational scali...