Does Amifostine Reduce Metabolic Rate? Effect of the Drug on Gas Exchange and Acute Ventilatory Hypoxic Response in Humans

• Main Authors: Jaideep J. Pandit (Author), Caroline Allen (Author), Evelyn Little (Author), Federico Formenti (Author), Adrian L. Harris (Author), Peter A. Robbins (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2015-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Amifostine is added to chemoradiation regimens in the treatment of many cancers on the basis that, by reducing the metabolic rate, it protects normal cells from toxic effects of therapy. We tested this hypothesis by measuring the metabolic rate (by gas exchange) over 255 min in 6 healthy subjects, a...