HIT-Cas9: A CRISPR/Cas9 Genome-Editing Device under Tight and Effective Drug Control

• Main Authors: Chen Zhao (Author), Yingze Zhao (Author), Jingfang Zhang (Author), Jia Lu (Author), Li Chen (Author), Yue Zhang (Author), Yue Ying (Author), Junjun Xu (Author), Shixian Wei (Author), Yu Wang (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The CRISPR/Cas9 enabled efficient gene editing in an easy and programmable manner. Controlling its activity in greater precision is desired for biomedical research and potential therapeutic translation. Here, we engrafted the CRISPR/Cas9 system with a mutated human estrogen receptor (ERT2), which re...