Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

• Autores principales: Hyeongmin Kim (Autor), Chung-Lyol Lee (Autor), Seohyun Lee (Autor), Tae Jin Lee (Autor), Iqra Haleem (Autor), Younghong Lee (Autor), Na Jung Hwang (Autor), Kyusun Shim (Autor), Dohyun Kim (Autor), Jaehwi Lee (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2019-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique and freez...