Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

• Main Authors: Hyeongmin Kim (Author), Chung-Lyol Lee (Author), Seohyun Lee (Author), Tae Jin Lee (Author), Iqra Haleem (Author), Younghong Lee (Author), Na Jung Hwang (Author), Kyusun Shim (Author), Dohyun Kim (Author), Jaehwi Lee (Author)
• Format: Book
• Published: MDPI AG, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique and freez...