A state of reversible compensated ventricular dysfunction precedes pathological remodelling in response to cardiomyocyte-specific activity of angiotensin II type-1 receptor in mice

• Autors principals: Georgia A. Frentzou (Autor), Mark J. Drinkhill (Autor), Neil A. Turner (Autor), Stephen G. Ball (Autor), Justin F. X. Ainscough (Autor)
• Format: Llibre
• Publicat: The Company of Biologists, 2015-08-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Cardiac dysfunction is commonly associated with high-blood-pressure-induced cardiomyocyte hypertrophy, in response to aberrant renin-angiotensin system (RAS) activity. Ensuing pathological remodelling promotes cardiomyocyte death and cardiac fibroblast activation, leading to cardiac fibrosis. The in...