Increased Mobile Zinc Regulates Retinal Ganglion Cell Survival via Activating Mitochondrial OMA1 and Integrated Stress Response

• Main Authors: Jiahui Tang (Author), Zhe Liu (Author), Jiaxu Han (Author), Jingfei Xue (Author), Liyan Liu (Author), Jicheng Lin (Author), Caiqing Wu (Author), Qi Zhang (Author), Siting Wu (Author), Canying Liu (Author), Haishun Huang (Author), Yuanyuan Fu (Author), Min Li (Author), Yehong Zhuo (Author), Yiqing Li (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinal ganglion cells (RGCs), the projection neurons of the eye, are irreversibly lost once the optic nerve is injured, which is a critical mechanism of glaucoma. Mobile zinc (Zn²⁺) levels rapidly increase in retinal interneuron amacrine cells and Zn²⁺...