Evaluation of antitumor potential of an anti-glypican-1 monoclonal antibody in preclinical lung cancer models reveals a distinct mechanism of action

• Main Authors: Minghua Li (Author), Yanhong Wang (Author), Xiaoyang Lin (Author), Haiqiang Yang (Author), Xiaolin Zhang (Author), Yun Bai (Author), Xiankun Li (Author), Lulu Zhang (Author), Feng Cheng (Author), Chuanhai Cao (Author), Qingyu Zhou (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: The main objective of this study was to investigate the antitumor effect of a mouse anti-human glypican-1 (GPC1) monoclonal antibody (mAb) on non-small cell lung carcinoma (NSCLC) and associated molecular mechanisms. Methods: The anti-proliferative and anti-migratory activities of anti-GPC1 mAb...