Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

• Main Authors: Jemy A. Gutierrez (Author), Wei Liu (Author), Sylvie Perez (Author), Gang Xing (Author), Gabriele Sonnenberg (Author), Kou Kou (Author), Matt Blatnik (Author), Richard Allen (Author), Yan Weng (Author), Nicholas B. Vera (Author), Kristin Chidsey (Author), Arthur Bergman (Author), Veena Somayaji (Author), Collin Crowley (Author), Michelle F. Clasquin (Author), Anu Nigam (Author), Melissa A. Fulham (Author), Derek M. Erion (Author), Trenton T. Ross (Author), William P. Esler (Author), Thomas V. Magee (Author), Jeffrey A. Pfefferkorn (Author), Kendra K. Bence (Author), Morris J. Birnbaum (Author), Gregory J. Tesz (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-alcoholic steatohepatitis (NASH), and related como...