Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives

• Main Authors: Marta Orlicka-Płocka (Author), Agnieszka Fedoruk-Wyszomirska (Author), Dorota Gurda-Woźna (Author), Paweł Pawelczak (Author), Patrycja Krawczyk (Author), Małgorzata Giel-Pietraszuk (Author), Grzegorz Framski (Author), Tomasz Ostrowski (Author), Eliza Wyszko (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, small compound-based therapies have provided new insights into the treatment of glioblastoma multiforme (GBM) by inducing oxidative impairment. Kinetin riboside (KR) and newly designed derivatives (8-azaKR, 7-deazaKR) selectively affect the molecular pathways crucial for cell growth by int...