Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

• Główni autorzy: Isabel M Vincent (Autor), Darren J Creek (Autor), Karl Burgess (Autor), Debra J Woods (Autor), Richard J S Burchmore (Autor), Michael P Barrett (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are...