Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

• Auteurs principaux: Isabel M Vincent (Auteur), Darren J Creek (Auteur), Karl Burgess (Auteur), Debra J Woods (Auteur), Richard J S Burchmore (Auteur), Michael P Barrett (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are...