Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model

• Main Authors: José Sereno (Author), Belmiro Parada (Author), Flávio Reis (Author), Fernanda X. Cunha (Author), Edite Teixeira-Lemos (Author), Patrícia Garrido (Author), Rui Pinto (Author), Petronila Rocha-Pereira (Author), Paula Neto (Author), José Ruivo (Author), Paulo Rodrigues-Santos (Author), Sara Nunes (Author), Alfredo Mota (Author), Arnaldo Figueiredo (Author), Frederico Teixeira (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of...